DAA FORMULA

It’s important to note that the human body hosts a diverse array of microbiomes, each residing in distinct parts of the body. Within this context, the equilibrium of the gut microbiota is indispensable for the harmonious operation of numerous physiological functions. However, this intricate balance can be significantly disrupted by the use of antibiotics, culminating in antibiotic associated diarrhoea, condition marked by perturbations in the gut microbiota due to these medicines. This dysbiosis can have far-reaching repercussions for human health.

The importance of a balanced gut microbiota

The gut microbiota is a complex consortium of microorganisms, predominantly bacteria, residing within the gastrointestinal tract. Its role in human health is multifaceted and encompasses:

  •  Digestive Function: Beneficial gut bacteria aid in the digestion of complex carbohydrates and fiber that the human digestive system cannot process alone.
  •  Immune System Regulation: A balanced gut microbiota is essential for immune system development and proper functioning. It helps prevent the colonization of pathogenic bacteria.
  •  Neurological and Psychological Health: The gut-brain axis, a bidirectional communication pathway between the gut and the brain, underscores the connection between gut health and mental well-being.
  •  Metabolism and Weight Management: Research indicates that the gut microbiota influences energy extraction from food and appetite regulation, affecting metabolism and body weight.
  • Protection Against Pathogens: A diverse microbiota provides protection against harmful pathogens by competing for resources and attachment sites.

Probiotics for Dysbiosis Prevention
  • Restoration of Microbial Balance: Probiotics are defined as live microorganisms that, when administered in adequate amounts, confer health benefits. When taken alongside antibiotics, they can aid in maintaining a healthier gut microbial balance by replenishing beneficial bacteria depleted by the antibiotic treatment.
  • Competitive Exclusion of Pathogens: Probiotics actively compete with pathogenic bacteria for limited resources and attachment sites within the gut. This competitive exclusion mechanism reduces the likelihood of pathogenic overgrowth.
  • Reduction in Antibiotic-Associated Diarrher: Antibiotic therapy often disrupts gut microbiota balance, leading to antibiotic-associated diarrhea (AAD). Clinical studies have shown that specific probiotic strains can significantly reduce the risk and severity of AAD by stabilizing the gut microbiota.
  • Prevention of Clostridium difficile Infections: In the context of antibiotic therapy, probiotics have demonstrated efficacy in preventing Clostridium difficile infections, a serious and recurrent health concern.

A well-balanced gut microbiota is integral to human health, affecting numerous physiological functions and providing protection against a range of health issues. Antibiotic treatment, while essential in combating bacterial infections, can disrupt this equilibrium, leading to antibiotic-induced dysbiosis. The judicious use of probiotics, informed by clinical studies, represents a scientifically grounded approach to preserving the integrity of the gut microbiota and reducing the associated risks of dysbiosis.

Bibliography:

-Horosheva, T. V., Vodyanoy, V., & Sorokulova, I. (2014). Efficacy of Bacillus probiotics in prevention of antibiotic‐associated diarrhoea: a randomized, double‐blind, placebo‐controlled clinical trial. JMM Case Reports, 1(3). https://doi.org/10.1099/jmmcr.0.004036

Study on 270 individuals concludes that probiotic treatment with Bacillus probiotics during antibiotic therapy signifi cantly decreased the incidence of antibiotic-associated diarrhoea and antibiotic-related adverse effects.Probiotics were well tolerated by patients with no side effects.

-Maity, C., Gupta PhD, A. K., Saroj, D. B., Biyani, A., Bagkar, P., Kulkarni, J., & Dixit, Y. (2021). Impact of a Gastrointestinal Stable Probiotic Supplement Bacillus coagulans LBSC on Human Gut Microbiome Modulation. Journal of dietary supplements, 18(6), 577–596.

https://doi.org/10.1080/19390211.2020.1814931

Spores of the genus B.coagulans are resistant to bile and the acidic environment of the stomach.They also stabilise the gut microbiota.

-Garvey SM, Mah E, Blonquist TM, Kaden VN, Spears JL. The probiotic Bacillus subtilis BS50, decreases gastrointestinal symptoms in healthy adults: a randomized, double-blind, placebo-controlled trial. Gut Microbes. 2022 Jan-Dec;14(1):2122668. Doi: 10.1080/19490976.2022.2122668. PMID: 36269141; PMCID: PMC9590435.

Clinical study on 76 people. The conclusion was that the results suggest that dietary supplementation with 2 × 109 CFU of Bacillus subtilis BS50 per day is a well-tolerated and safe strategy for relieving gastrointestinal symptoms in healthy adults.

– Dhongade, A. R., Joshi, S. S., Kulkarni, S. V., Jadhav, S. S., Nargundkar, N., Deshmukh, D., & Mehta, A. D. (2022). The efficacy and safety of a Bacillus probiotic combination for the treatment of acute diarrhea in children: A double-blind, randomized, placebo-controlled multicentric study. Pediatric Infectious Disease, 4(3), 86–91. https://doi.org/10.5005/p-journals-10081-1370

In this randomised, double-blind, parallel, placebo-controlled trial of 64 children with a mean age of 4.18 ± 3.0 years, of which 32 children with antibiotic-associated diarrhoea (AAD) and 32 children with acute infectious diarrhoea (AID) received randomised B. subtilis and B. coagulans probiotics or placebo daily for a period of 7 days. The results of this study conclude that B. subtilis and B. coagulans probiotics improved recovery and reduced the risk of acute infectious diarrhoea and AAD in children,with no adverse effects reported.

-Ianiro G, Rizzatti G, Plomer M, Lopetuso L, Scaldaferri F, Franceschi F, Cammarota G, Gasbarrini A. Bacillus clausii for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2018 Aug 12;10(8):1074. doi: 10.3390/nu10081074. PMID: 30103531; PMCID: PMC6116021.

Systematic review of clinical studies on B.clausii that concludes that the administration of Bacillus clausii significantly reduces the duration and frequency of diarrhoea.

-Acosta-Rodríguez-Bueno, C. P., Abreu Y Abreu, A. T., Guarner, F., Guno, M. J. V., Pehlivanoğlu, E., & Perez, M., 3rd (2022). Bacillus clausii for Gastrointestinal Disorders: A Narrative Literature Review. Advances in therapy, 39(11), 4854–4874. https://doi.org/10.1007/s12325-022-02285-0

The use of probiotic preparations containing B. clausii can be used to prevent and treat diarrhoea in adults and children, especially diarrhoea caused by B. clausii